Carbohydrate Chemistry

LEXINGTON PHARMACEUTICALS ANNOUNCES A MORE ECO-FRIENDLY, HIGH YIELDING PROCESS FOR MANUFACTURING SUCRALOSE OVER CURRENT PROCESSES

Indianapolis, March 17 - Industry Experts weigh in: conversion of sucrose to sucralose is known to be severely hampered by a difficult step which contributes greatly to the cost of its production. High reaction temperatures greatly lower yield and mass balance, and produce numerous byproducts. Historically, lowering the temperature and/or increasing the yields for this step on production scale has met with little success … that is until now.

Scientists at Lexington Pharmaceuticals Laboratories, LLC (Lexington) have discovered new conditions for preparing a key intermediate in the commercial production of the artificial sweetener sucralose, which is found in products such as Heartland Sweeteners' NevellaTM. It is widely acknowledged by those in the manufacturing business that finding some way to increase the yields and/or lower the reaction temperature to prepare this intermediate would be important to save money and energy. The new process discovered at Lexington is more environmentally friendly (greener) than published and/or patented processes: it boasts yields improvements in excess of 50%, dramatically reducing the waste stream, and operating temperatures reduced by 25%. This 20-30 oC reduction in reaction temperature is particularly significant in that 4 thousand Metric Tons of sucralose are produced each year, which translates to 8 billion BTUs saved (the equivalent of annually burning 320 acres of forestation, or 1.6% of the old wood acreage in California's Redwood National Forest). It is believed that this improved process (patents pending) will translate to substantially reducing the cost of manufacture (COM) of sucralose.

Lexington has been in operation since 2001. It is owned by businessman Ted Gelov, who also owns Heartland Sweeteners LLC, a leading manufacturer and marketer of tabletop sweeteners. Lexington was originally located in Lexington, Kentucky, but moved to Carmel, Indiana in 2008.

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